Cognitive Bias Modification for Alcohol Trial
A randomised controlled trial of Cognitive Bias Modification training during early recovery from alcohol dependence.
This cognitive bias modification (CBM) research project aimed to tests whether 4 short sessions of “brain-training”, using a laptop and joystick and delivered while clients are in residential withdrawal treatment (i.e., “detoxification”), helps people avoid relapse to alcohol use after discharge from treatment. The majority of people relapse to alcohol use after leaving withdrawal treatment, usually within a few weeks. One potential reason for this is that many people with an alcohol use disorder appear to develop “approach bias” towards alcohol, meaning an automatic tendency to approach alcohol in response to signals (such as images, smells, etc.) that remind them of alcohol. This “approach bias” might not be fully under one’s conscious control.
Our randomised controlled trial (RCT) compared a computerised CBM training task designed to dampen approach bias to another similar task that used the same images and equipment, but which was not specifically designed to change approach bias, to see whether the CBM task leads to higher rates of abstinence from alcohol after people leave residential withdrawal treatment. We recruited 300 participants from 4 residential withdrawal units around Melbourne from 2017-2019. We followed up participants 2 weeks, 3 months, 6 months, and 1 year after they left withdrawal treatment.
Turning Point team
Associate Professor Antonio Verdejo-Garcia (Monash University), Dr Petra Staiger (Deakin University), Dr Kate Hall (Deakin University), Professor Anthony Harris (Monash University), Associate Professor Jarrad Lum (Deakin University), Associate Professor John Reynolds (Monash University), Dr Martyn Lloyd-Jones (St Vincent’s Hospital Melbourne), Prof Reinout Wiers (University of Amsterdam), and Dr Yvonne Bonomo (St Vincent’s Hospital Melbourne).
National Health and Medical Research Council (NHMRC: project grant 1124604)
Learn more about this project
- This project is a follow-up to a pilot study which examined CBM in a smaller group of people undergoing alcohol withdrawal treatment, who were mainly recruited from Turning Point’s withdrawal unit, Wellington House. Read more.
- An additional related pilot project we conducted at Wellington House tested combining CBM with working memory training in alcohol withdrawal patients. Read more.
- Manning, V., Garfield, J. B. B., Campbell, S., Reynolds, J., Staiger, P. K., Lum, J. A. G., Hall, K., Wiers, R. W., Lubman, D. I., & Verdejo-Garcia, A. (2018). Protocol for a randomised controlled trial of cognitive bias modification training during inpatient withdrawal from alcohol use disorder. Trials, 19, 598. Doi: 10.1186/s13063-018-2999-3.
- Manning, V., Mroz, K., Garfield, J, B. B., Staiger, P. K., Hall, K., Lubman, D. I., & Verdejo-Garcia, A. (2019) Combining approach bias modification with working memory training during inpatient alcohol withdrawal: An open-label pilot trial of feasibility and acceptability. Substance Abuse Treatment, Prevention, and Policy 14; 24, DOI: 10.1186/s13011-019-0209-2.
- Manning, V., Staiger, P., Hall, K., Garfield, J.B.B., Flaks, G., Leung, D. Hughes, L., Lum, J., Lubman, D.I. & Verdejo-Garcia, A. (2016). Cognitive Bias Modification Training During Inpatient Alcohol Detoxification Reduces Early Relapse: A Randomised Controlled Trial. Alcoholism: Clinical and Experimental Research, 40(9), 2011-2019.